repercussões cerebrais

Review - Neuropsychiatric and Behavioral Involvement in AAS Abusers

Giuseppe Bertozzi, Monica Salerno, Cristoforo Pomara and Francesco Sessa

Abstract: Background and Objectives: Anabolic androgenic steroids (AASs) are a complex group of molecules that include both steroidal androgens and synthetic compounds, derived from testosterone. AASs are commonly used to support pharmacological therapy in cases of primary or secondary hypogonadism, major burns, and neoplastic cachexia. Their prolonged and supra-physiological consumption can provoke several adverse effects on various organs and systems. Among these, the physiopathological mechanisms that induce neuropsychiatric disorders related to AAS abuse are poorly known. For this reason, the proposed review aims to retrace the pathway of action of testosterone to focus on the effects on the central nervous system and specifically highlight the effects of AASs on neuropsychiatric and behavioral functions, as well as on lifestyle. Materials and Methods: This review was conducted using PubMed and Google Scholar databases. On these database websites, we searched for articles from 1 January 1980 to March 2019 using the key terms: “AAS,” “Anabolic Androgenic Steroids,” “brain,” and “neurology.” Results: The use of AASs through self-administration yields circulating androgens levels, inducing neuron apoptosis, which is linked to thinner cortex and, in general, less cortical volume. The same alterations affect the putamen. These differences were more evident when correlated with longer use. From a functional point of view, prolonged AAS consumption seemed to be related to lower connectivity between amygdala and frontal, striatal, limbic, hippocampal and visual cortical areas. On the other hand, AAS use seems
to negatively condition the positive effects of the sport exercise, reducing its important anti-apoptotic and pro-proliferative functions on the hippocampus, implicated in anxiolytic control.

Dismorfia muscular

Palestra - XIV Congresso CHLA

Confira a palestra "Dismorfia muscular: uso e abuso dos anabólicos androgênicos" do Dr. Clayton Macedo.

Páginas de PALESTRA DR CLAYTON EFEITOS COLATERAIS DOS ESTEROIDES

Palestra

Confira a palestra "Os efeitos colaterais do uso de esteroides anabolizantes e similares realmente ocorrem?"do Dr. Clayton Macedo.

Modelo de post

Modelo de post

Faça download do modelo de post para compartilhar seu caso clínico.

Folder do Programa #BombaTôFora

Faça download do Folder do Programa (se você quiser mandar imprimir cópias e ajudar na divulgação, entre em contato conosco)

Botton do Programa #BombaTôFora

Faça download do botton do Programa (se você quiser mandar confeccionar bottons e ajudar na divulgação, entre em contato conosco)

Palestra de apresentação do Programa #BombaTôFora

Faça download da palestra de apresentação do Professor Dr. Clayton Luiz Dornelles Macedo, idealizador do programa #BombaTôFora